منابع مشابه
The new genomic editing system (CRISPR)
Over the past decades, progression in genetic element manipulation, and consequently, the treatment of diseases has been remarkable. It is worth noting that these genetic manipulations perform at different levels, including DNA and RNA. The earlier genomic editing techniques, including MN, ZFN , TALEN , performing their functions by creating double-stranded breaks (DSBs), and after breakage, th...
متن کامل5 Statistical Data Editing
Statistical Data Editing (SDE) is the process of checking data for errors and correcting them. Winkler (1999) defined it as the set of methods used to edit (i.e., clean up) and impute (fill in) missing or contradictory data. The result of SDE is data that can be used for analytic purposes. Editing literature goes back to the 1960s with the contributions of Nordbotten (1965), Pritzker, et al. (1...
متن کامل5' end maturation and RNA editing have to precede tRNA 3' processing in plant mitochondria.
We report the characterization and partial purification of potato mitochondrial RNase Z, an endonuclease that generates mature tRNA 3' ends. The enzyme consists of one (or more) protein(s) without RNA subunits. Products of the processing reaction are tRNA molecules with 3' terminal hydroxyl groups and 3' trailers with 5' terminal phosphates. The main processing sites are located immediately 3' ...
متن کاملUridylate-specific 3' 5'-exoribonucleases involved in uridylate-deletion RNA editing in trypanosomatid mitochondria.
In kinetoplastid protists, maturation of mitochondrial pre-mRNAs involves the insertion and deletion of uridylates (Us) within coding regions, as specified by mitochondrial DNA-encoded guide RNAs. U-deletion editing involves endonucleolytic cleavage of the pre-mRNA at the editing site followed by U-specific 3'-5'-exonucleolytic removal of nonbase-paired Us prior to ligation of the two mRNA clea...
متن کاملFrom End to End: tRNA Editing at 5'- and 3'-Terminal Positions
During maturation, tRNA molecules undergo a series of individual processing steps, ranging from exo- and endonucleolytic trimming reactions at their 5'- and 3'-ends, specific base modifications and intron removal to the addition of the conserved 3'-terminal CCA sequence. Especially in mitochondria, this plethora of processing steps is completed by various editing events, where base identities a...
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ژورنال
عنوان ژورنال: The Journal of the Institute of Television Engineers of Japan
سال: 1977
ISSN: 1884-9644
DOI: 10.3169/itej1954.31.10_765